New research identifies a mechanism of action for the GLP-1 receptor, the target of GLP-1 diabetes drugsThe new work shows that GLP‑1 receptors do more than signal briefly at the cell surface: they form long‑lasting “signaling hubs” at contact sites with the endoplasmic reticulum, where they reshape mitochondria to improve β‑cell survival and insulin secretion.[1]## What this study found- After activation, GLP‑1 receptors cluster at specialized membrane–ER contact sites instead of simply being internalized and degraded, allowing sustained intracellular signaling.[1]- From these hubs, GLP‑1 signaling reorganizes mitochondrial networks and supports healthier mitochondrial function in β‑cells, which helps them resist metabolic stress and continue secreting insulin.[1]## Why it matters clinically- This mechanism helps explain why GLP‑1 agonists protect β‑cell function beyond their immediate effect on insulin release after a meal.[1]- It suggests new therapeutic strategies: drugs that stabilize or enhance these GLP‑1 signaling hubs might give more durable β‑cell protection in type 2 diabetes.[1]Citations:[1] New research identifies a mechanism of action for the GLP … https://www.imperial.ac.uk/news/articles/medicine/metabolism-dl